GETTING MY TRASTUZUMAB BIOSIMILAR TO WORK

The phosphorylated HER3 presents docking sites for p85 subunit of PI3K. The thoroughly activated PI3K complicated is generated by binding of p110 subunit of PI3K to p85 which has the capacity to deliver PIP3 via phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at each threonine and serin p